2014 poročiLo AnnUAL Letno RePoRt

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Letno

poročiLo AnnUAL

RePoRt

2014

Letno poročiLo / AnnUAL report2014

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Letno poročilo 2014 / Annual report 2014

Poslanstvo Kemijskega inštituta

- pridobivanje novih znanj s področja kemije in sorodnih ved;

- prenos pridobljenega znanja v industrijo;

- prenos pridobljenega znanja na mlajše generacije.

- expand knowledge of chemistry and associated studies;

- apply newly acquired knowledge in industry;

- transfer knowledge to younger generations.

Mission

Kalcijev hidroksi apatit »Sinergija okroglega in oglatega« / Calcium hydroxyapatite “Synergy of Round and Square” (Gregor Kapun)

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Kazalo / index

Uvodna beseda direktorja / Director’s Introduction 4

Vodstvo inštituta / Institute Management 6

Pregled poslovanja inštituta / Overview of the Institute’s Business Operation 8

Zaposleni in izobraževanje / Employees and education 12

Doktorati, magisteriji in diplome v letu 2014 / Doctoral, Master’s and Graduate Theses in 2014 14

Objave v letu 2014 / Publications in 2014 15

Mednarodno sodelovanje 2014 / International Cooperation 2014 20

Uspehi, nagrade in priznanja v letu 2014 / Achievements, awards and recognitions in 2014 22

Patenti, inovacije / Patents, innovations 27

Zaposleni v splošnem sektorju / General sector – employees 32

Laboratorij za računalniške bioznanosti in bioinformatiko / Laboratory for Biocomputing and Bioinformatics 34

Laboratorij za kemometrijo / Laboratory of Chemometrics 38

Laboratorij za analizno kemijo / Analytical Chemistry Laboratory 44

Laboratorij za okoljske vede in inženirstvo / Laboratory for Environmental Sciences and Engineering 50

Laboratorij za prehrambeno kemijo / Laboratory for Food Chemistry 56

Laboratorij za polimerno kemijo in tehnologijo / Laboratory for Polymer Chemistry and Technology 60 Laboratorij za anorgansko kemijo in tehnologijo / Laboratory for Inorganic Chemistry and Technology 64

Laboratorij za kemijo materialov / Laboratory for Materials Chemistry 68

Laboratorij za molekularno biologijo in nanobiotehnologijo / Laboratory for Molecular Biology and Nanobiotechnology 74

Laboratorij za biotehnologijo / Laboratory of Biotechnology 80

Laboratorij za katalizo in reakcijsko inženirstvo / Laboratory for Catalysis and Chemical Reaction Engineering 86

Laboratorij za strukturo biomolekul / Laboratory of Biomolecular Structure 92

(NMR) Nacionalni center za NMR spektroskopijo visoke ločljivosti / Slovenian NMR Centre 96 (CVTA) Center za validacijske tehnologije in analitiko / Centre for Validation Technologies and Analytics 102

Laboratorij za molekularno modeliranje / Laboratory for Molecular Modeling 106

Izbrana bibliografija / Selected Bibliography 110

Slika na naslovnici: Precipitiran CaCO3 »Polno v votlem« / Photo on coverpage: Precipitated CaCO3 “Fullness in Hollow” (Gregor Kapun)

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UVODNA BESEDA DIREKTORjA / THE

DIRECTOR’S FOREwORD

The introductory speech for the Report on the Activities of the National Institute of Chemistry in 2014 should have been written by our dear colleague prof. dr. janko jamnik but he is unfortunately no longer among us. Thus, the first words of this introduction are intended for him. I respected dr. janko jamnik highly. He was in charge of the National Institute of Chemistry since 2008 and his main goal was to strengthen the position of the Institute in the global scientific field, which he largely succeeded in achieving. He drew excellent researchers to the National Institute of Chemistry and created a true research and innovation environment, including an ambitious network of researchers and their teams, institutes, centres, companies etc.

He was very innovative and had an exceptional capability for connecting the world of science with industry. He believed in a better society where knowledge, achievements and innovation play an important role. He also believed in young people, knew how to encourage them and also enable the best of them to perform research at the laboratories of the Institute.

Tragic fate stopped him in the middle of his path. we shall miss his cheerful, optimistic view of the future, his commitment to managing the Institute and his efforts to place the Institute among the best.

The achievements of the National Institute of Chemistry under the management of prof. jamnik had a resounding success on the Slovenian and global levels, even in 2014.

we have demonstrated our scientific excellence with publications in the renowned Nature Family group of journals. Colleagues from the Laboratory of Biotechnology, the EN-FIST Centre of Excellence and the Faculty of Computer and Information Science of the University of Ljubljana have, using proteins, structured logical circuits in human cells so that they process input signals based on a similar logic to electronic computers. Besides this, they succeeded in preparing genetic switches that could function simultaneously in cells, meaning that the cells could save more information and their operation could be directed in an easier manner. These discoveries promise a more accurate control of the operation and response of cells to various signals, which could primarily be useful for medical and diagnostic purposes. The new discoveries were published in Nature Chemical Biology and Nature Communications. The latter also published a presentation of a new four-stranded structure with a guanine-rich DNA sequence that surprisingly does not form a G-quadruplex. It was discovered by the colleagues of the National Institute of Chemistry’s NMR centre, the EN-FIST Centre of Excellence and the Faculty of Chemistry and Chemical Technology of the University of Ljubljana. The new guanine-rich structure expands the current repertoire of known DNA structures and provides a fundamental insight into forces that drive the folding of the oligonucleotide DNA chain.

Prof. Janko Jamnik, PhD, Director of the National Institute of Chemistry from 2008 to 2014

Uvodne besede k Poročilu o delu Kemijskega inštituta v letu 2014 bi moral napisati cenjeni kolega prof. dr. janko jamnik, a ga žal ni več med nami. Zato so prve besede v tem uvodu namenjene prav njemu. Dr. janka jamnika sem zelo cenil.

Kemijski inštitut je vodil od leta 2008, njegov glavni cilj je bil utrditev položaja Kemijskega inštituta v svetovni znanstveni sferi, in to mu je v veliki meri uspelo. Na Kemijski inštitut je pritegnil odlične raziskovalce in ustvaril pravi raziskovalno- inovativen ekosistem, ki vključuje ambiciozno mrežo raziskovalcev in njihovih timov, inštitutov, centrov, podjetij … Bil je zelo prodoren in je imel izjemno sposobnost

povezovanja sveta znanosti in industrije. Verjel je v boljšo družbo, kjer imajo pomembno vlogo znanje, dosežki in inovacije. Zelo je zaupal v mlade ljudi, znal jih je spodbuditi in najboljšim je tudi omogočil, da so raziskovali v laboratorijih inštituta.

Tragična usoda ga je ustavila sredi njegove poti. Pogrešali bomo njegov vedri, optimistični pogled v prihodnost in njegovo zavzetost pri vodenju inštituta ter umeščanju inštituta med najodličnejše.

Dosežki Kemijskega inštituta pod vodstvom prof. jamnika so tudi v l. 2014 odmevali v slovenskem in svetovnem prostoru.

Našo znanstveno odličnost smo izkazali z objavami v prestižni skupini revij Nature Family. Sodelavci Laboratorija za biotehnologijo, Centra odličnosti EN-FIST in Fakultete za računalništvo in informatiko Univerze v Ljubljani so z uporabo proteinov skonstruirali logična vezja v človeških celicah, tako da obdelujejo vhodne signale na podlagi podobne logike kot elektronski računalniki. Poleg tega jim je uspelo pripraviti genska stikala, ki bi lahko vzporedno delovala v celicah, kar pomeni, da bi lahko v celice shranili več informacij in bi lažje usmerjali njihovo delovanje. Obetajo si, da bodo te iznajdbe omogočile bolj natančno kontrolo delovanja in odziva celic na različne signale, kar bi bilo lahko uporabno predvsem za medicinske in diagnostične namene. Novi Prof. dr. Janko Jamnik, direktor Kemijskega inštituta od leta 2008 do 2014

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we have also demonstrated our scientific excellence with numerous publications in other renowned international publications. For example, colleagues from the NMR Centre discovered a new way of forming DNA G-quadruplexes and published it in the Angewandte Chemie journal. This allowed for a structural, thermodynamic and kinetic evaluation of the intermediate states, which represents an important step in the efforts to explain the general principles according to which the G-quadruplexes take on their native fold. They also participated in the discovery of a new method for the direct detection of sulfate transport in lipid bilayers, which was published in Chemical Science. Colleagues from the Laboratory of Biotechnology, the Laboratory for Biocomputing and Bioinformatics and colleagues from the University of Tubingen discovered the molecular mechanism of the development of lymphoma and published it in the Blood journal. New findings from the studies of molecular interactions of proteins that participate in the biosynthesis of proteins and the cytoskeleton, with the participation of colleagues from the Laboratory for Molecular Biology and Nanobiotechnology, were published in the journals Nucleic Acid Research and EMBO reports. A comprehensive overview of their achievements in the field of damage to cell lipid membranes with protein pores, which are important in the field of bacterial pathogenesis and the immune system of vertebrates, was published in Trends in Biochemical Sciences. Nucleic Acid Research also presented the web server ProBiS-ligands, which was developed by colleagues from the Laboratory for Molecular Modelling. Their greatest achievements are also included in a comprehensive overview of the field of bioinformatics forecasting of protein binding sites presented in Current Opinion in Structural Biology.

Colleagues from the Laboratory for Materials Chemistry used an in operando analytical method developed in their group and in an article published in ChemSusChem explained the differences in the mechanism of the operation of the Li-S battery in the presence of two different electrolytes.

Scientific excellence is also confirmed by our researchers, who received a series of recognitions and awards in Slovenia and abroad (described on pages 22-26). I would like to point out Prof. Dr. Roman jerala, who received a decoration from the Republic of Slovenia - a medal for accomplishments in the promotion of Slovenian science and higher education in the international arena.

In 2014, we continued our investments in improving the quality of the work environment at the Institute and started renovating the extension and the old building of the National Institute of Chemistry, for which we acquired three million two hundred thousand Euros from the European Regional Development Fund. with the above investment, the National Institute of Chemistry will renovate some laboratories encompassing more than 1,500 m2 and will purchase new research equipment. The goal of the investment is to ensure quality and modern infrastructure.

I wish the colleagues from the Institute a successful continuation of their path, which was planned by Prof.

jamnik, in order for them to use their top science to contribute to the progress of society, development and prosperity.

Acad. Prof. Dr. janez Levec Acting Director odkritji sta objavljeni v Nature Chemical Biology in Nature

Communications. V slednji reviji je predstavljena tudi nova štirivijačna prostorska struktura z gvanini bogatega DNK- zaporedja, ki presenetljivo ne tvori G-kvadrupleksa. Odkrili so jo sodelavci NMR centra, Centra odličnosti EN-FIST in Fakultete za kemijo in kemijsko tehnologijo Univerze v Ljubljani. Nova z gvanini bogata struktura razširja trenuten repertoar znanih struktur DNK in omogoča bistven razmislek, katere sile vodijo zvijanje oligonukleotidne DNK-verige.

Poleg tega smo znanstveno odličnost potrdili tudi s številnimi objavami v drugih uglednih mednarodnih publikacijah.

Npr. sodelavci NMR centra so odkrili nov način tvorbe DNK G-kvadrupleksov in ga objavili v reviji Angewandte Chemie.

Pri tem so lahko strukturno, termodinamsko in kinetično ovrednotili intermediatna stanja, kar predstavlja pomemben korak v prizadevanjih, da bi pojasnili splošna načela, po katerih G-kvadrupleksi prevzamejo nativno zvitje. Sodelovali so tudi pri odkritju nove metode za direktno detektiranje prenosa sulfata v lipidnih dvoslojih, objavljene v reviji Chemical Science. Sodelavci Laboratorija za biotehnologijo, Laboratorija za računalniške bioznanosti in bioinformatiko ter sodelavci Univerze v Tuebingenu so odkrili molekulski mehanizem razvoja limfoma in ga objavili v reviji Blood. Novi izsledki raziskav molekulskih interakcij proteinov, ki sodelujejo pri biosintezi proteinov in celičnem skeletu, pri katerih so sodelovali sodelavci Laboratorija za molekularno biologijo in nanobiotehnologijo, so objavljeni v revijah Nucleic Acid Research in EMBO reports. Celovit pregled svojih dosežkov na področju poškodb celičnih lipidnih membran s proteinskimi porami, ki so pomembni za področja bakterijske patogeneze in imunskega sistema vretenčarjev, pa so objavili v reviji Trends in Biochemical Sciences. V Nucleic Acid Research je predstavljen tudi spletni strežnik ProBiS-ligands, ki so ga razvili sodelavci Laboratorija za molekularno modeliranje.

Njihovi najpomembnejši dosežki so vključeni tudi v celovit pregled področja bioinformatičnega napovedovanja proteinskih vezavnih mest, ki so ga podali v reviji Current Opinion in Structural Biology. Sodelavci Laboratorija za kemijo materialov so uporabili doma razvito analitsko metodo in operando in v prispevku, objavljenem v reviji ChemSusChem, razložili razlike v mehanizmu delovanja Li-S- akumulatorja v prisotnosti dveh različnih elektrolitov.

Znanstveno odličnost potrjujejo tudi naši raziskovalci, ki so prejeli vrsto priznanj in nagrad doma in v tujini (opisano na straneh 22–26). Izpostavil bi prof. dr. Romana jeralo, ki je prejel državno odlikovanje Republike Slovenije, medaljo za zasluge pri uveljavljanju slovenske znanosti in visokega šolstva v mednarodnem prostoru.

V letu 2014 smo še naprej investirali v izboljšanje kakovosti delovnega okolja na inštitutu in začeli obnavljati prizidek in staro stavbo Kemijskega inštituta, za kar smo pridobili tri milijone dvesto tisoč sredstev Evropskega sklada za regionalni razvoj. Z omenjeno naložbo bo Kemijski inštitut prenovil nekaj laboratorijev, ki obsegajo preko 1.500 m² tlorisnih površin, in nakupil novo raziskovalno opremo. Cilj investicije je zagotoviti kakovostno in sodobno infrastrukturo.

Ob koncu sodelavcem inštituta želim uspešno nadaljevanje poti, v smeri, ki jo je začrtal prof. jamnik, da z vrhunsko znanostjo prispevajo k družbenemu napredku, razvoju in blaginji.

Akademik prof. dr. janez Levec v. d. direktorja

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Vodstvo / Management

Direktor / Director

prof. dr. janko jAMNIK (do/until 19.12.2014)

akademik prof. dr. janez LEVEC (od/from 22.12.2014)

Pomočniki direktorja / Assistant directors Urška MIHELjAK ŽABOT (do/until 19.11.2014)

Urša jERŠE (v. d. pomočnice direktorja / Acting Assistant Director, od/from 20.11.2014)

Mitja ČERMELj (od/from 7.4.2014)

Člani upravnega odbora / Board of Governors

akademik prof. dr. janez Levec, predsednik / president (do / until 22.12.2014)

dr. Aleš Mihelič, predsednik / president (od / from 22.12.2014)

dr. Marta Svoljšak, podpredsednica / vice-president prof. dr. janvit Golob

dr. Gorazd Hribar

VodstVo inštituta / institute ManageMent

Raziskovalni sektor Sektor skupnih družb

področje za splošne zadeve

področje za ekonomsko finančne zadeve

sistem kakovosti

Znanstveni svet Direktor Direktorjeva pisarna

UPRAVNI ODBOR

ORGANIZACIjSKA SHEMA

L10 | laboratorij za kemijo materialov

L11 | laboratorij za molekularno biologijo in nanobiotehnologijo L12 | laboratorij za biotehnologijo

L13 | laboratorij za katalizo in reakcijsko inženirstvo

L14 | laboratorij za strukturo biomolekul

L15 | (nMr) nacionalni center za nMr spektroskopijo visoke ločljivosti

L16 | (CVta) Center za validacijske tehnologije in analitiko

L17 | laboratorij za molekularno modeliranje

L01 | laboratorij za računalniške bioznanosti in bioinformatiko L03 | laboratorij za kemometrijo L04 | laboratorij za analizno kemijo

L05 | laboratorij za okoljske vede in inženirstvo

L06 | laboratorij za prehrambeno kemijo

L07 | laboratorij za polimerno kemijo in tehnologijo

L09 | laboratorij za anorgansko kemijo in tehnologijo

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Člani znanstvenega sveta / Scientific Council

prof. dr. Simona Golič Grdadolnik, predsednica / president

dr. Robert Dominko, podpredsednik / vice-president prof. dr. Gregor Anderluh

prof. dr. Miran Gaberšček prof. dr. Roman jerala doc. dr. janez Mavri prof. dr. janez Plavec

prof. dr. Nataša Zabukovec Logar dr. Ema Žagar

Častni člani / Honorary Members

prof. dr. Tihomir NOVAKOV, od / from 19. 12. 1986 prof. dr. walter STEINER, od / from 15. 6. 1994 prof. dr. john R. HELLIwELL, od / from 21. 10. 1996 prof. dr. joachim MAIER, od / from 17. 4. 1996 akad. prof. dr. Dušan HADŽI, od / from 9. 10. 2001 prof. dr. joseph wANG, od / from 15. 6. 2007 prof. dr. Milan RANDIĆ, od / from 27. 9. 2007

Zaslužni raziskovalci Kemijskega inštituta / Researcher Emeritus

akad. prof. dr. Dušan Hadži (20.6.2011) prof. dr. jure Zupan (20.6.2011) dr. Božidar Ogorevc (19.12.2012) prof. dr. Venčeslav Kaučič (26.2.2014) prof. dr. Boris Orel (28.5.2014)

ORGANIZATIONAL SCHEME

Research Sector General Sector

general and legal Matters Finance and accounting

Quality system

Scientific Council Director Director’s Office

BOARD OF GOVERNORS

L10 | laboratory for Materials Chemistry

L11 | laboratory for Molecular Biology and nanobiotechnology L12 | laboratory of Biotechnology

L13 | laboratory for Catalysis and Chemical reaction engineering

L14 | laboratory of Biomolecular structure

L15 | slovenian nMr Centre

L16 | Centre for Validation technologies and analytics L17 | laboratory for Molecular Modeling L01 | laboratory for Biocomputing

and Bioinformatics L03 | laboratory of Chemometrics L04 | analytical Chemistry laboratory

L05 | laboratory for environmental sciences and engineering L06 | laboratory for Food Chemistry

L07 | laboratory for polymer Chemistry and technology L09 | laboratory for inorganic

Chemistry and technology

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PREGLED POSLOVANjA INŠTITUTA

V letu 2014 se je nadaljevalo zmanjševanje obsega javnih sredstev, namenjenih za raziskovalno dejavnost, kar je močno zaznamovalo poslovanje Kemijskega inštituta (KI). Prav tako je še vedno opazna previdnost industrijskih partnerjev pri namenjanju sredstev za raziskave in razvoj. Delno povečanje prihodkov je posledica zaključevanja nekaterih programov in projektov konec leta 2014, vendar pa smo se na inštitutu prilagodili pričakovanemu krčenju sredstev za izvajanje javne službe ter počasi rastočemu obsegu opravljenih raziskovalnih storitev za domače naročnike z omejevanjem rasti stroškov ter planiranemu zniževanju stroškov v prihodnjem letu. Tudi v letu 2014 se je nadaljevalo uspešno pridobivanje projektov, financiranih s strani Evropske unije in v sodelovanju s tujimi

industrijskimi partnerji.

Inštitut je leto 2014 zaključil s presežkom prihodkov nad odhodki po davkih v višini 75.493 EUR, upoštevajoč presežek prihodkov iz prejšnjih let, namenjenih pokritju odhodkov obračunskega obdobja, ki so znašali 87.302 EUR. Dosežen poslovni rezultat inštituta je predvsem

posledica presežka prihodkov nad odhodki iz naslova prodaje blaga in storitev na trgu, ki je znašal 60.111 EUR z upoštevanjem davka od dohodkov pravnih oseb.

Inštitut je v letu 2014 realiziral celotne prihodke v višini 14.733.782 EUR; to predstavlja nominalno 7-odstotno povečanje glede na leto 2013, predvsem na račun zaključevanja programov in projektov konec leta 2014.

Inštitut je v letu 2014 realiziral celotne odhodke v višini 14.728.606 EUR, kar v primerjavi z letom 2013 predstavlja 6,9-odstotno povečanje. Gibanje stroškov sledi

realiziranim prihodkom.

PRIHODKI v EUR 2014 2013 Struktura 2014 (%) INDEKS 2014/2013

Raziskovalni programi 4.626.370 3.566.039 31 130

Infrastrukturni programi 743.106 692.047 5 107

Raziskovalni projekti 1.342.117 1.438.437 9 93

Sofinanciranje aplikativnih projektov 189.072 292.019 1 65

Ustanoviteljske obveznosti 1.930.080 2.065.576 13 93

Mladi raziskovalci 1.520.095 1.650.638 10 92

Domači trg 2.121.368 2.378.520 15 89

Tuji trg 1.010.452 805.498 7 125

Drugi prihodki 1.338.424 968.111 9 138

SKUPAJ PRIHODKI 14.821.084 13.856.884 100 107

ODHODKI v EUR 2014 2013 Struktura 2014 (%) INDEKS 2014/2013

Stroški materiala -2.051.958 -1.861.501 14 110

Stroški storitev -2.674.507 -2.492.260 18 107

Amortizacija -1.579.537 -1.467.991 11 108

Stroški dela -8.290.704 -7.825.876 56 106

Drugi odhodki -131.898 -125.686 1 105

SKUPAJ ODHODKI -14.728.606 -13.773.314 100 107

REZULTAT POSLOVANJA 92.478 83.570 - 111

14.821.084 €

CELOTNI PRIHODKI

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OVERVIEw OF INSTITUTE OPERATIONS

The reduced volume of public funds invested in research activities continued in 2014, leaving a strong mark on the operations of the National Institute of Chemistry. It is also evident that industry partners are still being careful when allocating funding for research and development. The partial increase in revenue is the result of the programmes and projects that were brought to completion at the end of 2014.

The Institute adapted to the expected reduction in funding for providing public services and the languid growth in the number of research services performed for domestic clients by limiting the increase of costs while simultaneously planning cost reductions for the upcoming year. In 2014, we successfully obtained additional projects financed by the European Union and in collaboration with foreign industry partners.

The Institute concluded 2014 with an excess of revenues over expenses after tax in the amount of €75,493, taking into account the revenue surplus from previous years intended to cover expenses for the accounting period amounting to €87,302. The achieved operating result is primarily due to the excess of revenues over

expenses in the sale of goods and services on the market amounting to €60,111, taking into account corporate income tax. The total revenues for 2014 amounted to €14,733,782, representing a nominal 7%

increase compared to 2014, primarily on account of the completion of programmes and projects at the end of 2014. In 2014, the Institute realised expenses in the total amount of €14,728,606, representing a 6.9% increase compared to 2013. The changes in costs follow the realised revenue.

REVENUES in € 2014 2013 Structure 2014 (%) INDEX 2014/2013

Research programmes 4,626,370 3,566,039 31 130

Infrastructure programmes 743,106 692,047 5 107

Research projects 1,342,117 1,438,437 9 93

Co-financing applied projects 189,072 292,019 1 65

Founder’s obligations 1,930,080 2,065,576 13 93

Early-stage researchers 1,520,095 1,650,638 10 92

Domestic market 2,121,368 2,378,520 15 89

Foreign markets 1,010,452 805,498 7 125

Other revenues 1,338,424 968,111 9 138

TOTAL REVENUES 14,821,084 13,856,884 100 107

EXPENSES in € 2014 2013 Structure 2014 (%) INDEX 2014/2013

Costs of materials -2,051,958 -1,861,501 14 110

Costs of services -2,674,507 -2,492,260 18 107

Depreciation/amortisation -1,579,537 -1,467,991 11 108

Labour costs -8,290,704 -7,825,876 56 106

Other expenses -131,898 -125,686 1 105

TOTAL EXPENDITURE -14,728,606 -13,773,314 100 107

OPERATING RESULT 92,478 83,570 - 111

14,821,084 €

TOTAL REVENUES

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Investicije

V letu 2014 je inštitut investiral v osnovna sredstva 1.489.855 EUR. Investicije je omogočilo tudi uspešno pridobivanje zunanjih virov financiranja. V tem letu sta se začela projekta obnove prizidka in stare stavbe Kemijskega inštituta, ki bosta realizirana v letu 2015. Ocenjena vrednost obnove prizidka Kemijskega inštituta je 2.237.029 EUR, vrednost obnove stare stavbe Kemijskega inštituta pa je 1.714.520 EUR. Obe obnovi bo sofinanciralo resorno ministrstvo – sredstva Evropskega sklada za regionalni razvoj v višini 85 % in Republike Slovenije v višini 15 % pridobljenih sredstev.

V letu 2014 je inštitut investiral v opremo 1.244.704 EUR, v nepremičnine 178.288 EUR in imel za 66.863 EUR ostalih investicij.

Med novimi pridobitvami raziskovalne opreme večje vrednosti so predvsem:

• masni spektrometer z ionizacijo Agilent

• laser Ablation Analyte G2 EXCIMER

• aparatura za merjenje molekularnih interakcij

• tekočinski kromatograf (HPLC) Agilent 1260 Infinity

• Potenciostat MPG2

Pridobljeni in zaključeni raziskovalni projekti

V letu 2014 je inštitut začel izvajati oziroma sodelovati pri izvajanju 20 projektov javne agencije za raziskovalno dejavnost Republike Slovenije (ARRS):

• štirje aplikativni projekti (eden kot nosilec) z ocenjenimi prihodki na letni ravni v višini 126.720,62 EUR;

• 14 temeljnih projektov (šest kot nosilec) z

ocenjenimi prihodki na letni ravni v višini 585.317,72 EUR;

• dva nova podoktorska projekta s prihodki na letni ravni v višini 106.522 EUR.

V letu 2014 je KI zaključil temeljne, aplikativne in podoktorske projekte s prihodki leta 2014 v višini 436.249,31 EUR (872.498,62 EUR prihodkov letno).

Dejavnosti inštituta v letu 2014:

• Kot koordinator je vodil evropski strateški projekt DeFishGear v skupni vrednosti 5,3 mio EUR (vrednost projekta za KI je 675.112 EUR, od tega je 641.357 EUR sofinanciranih). Prihodki v letu 2014 so znašali 132.140,59 EUR.

• Sodeloval je pri šestih projektih 7. okvirnega programa EU. Prihodki v letu 2014 so znašali 445.516,18 EUR.

• Koordiniral je izvajanje projekta EUROLIS 7.

okvirnega programa Evropske skupnosti v skupni vrednosti 3,9 mio EUR (vrednost projekta za KI je 782.630 EUR, od tega je sofinanciranih 633.830 EUR). Prihodki v letu 2014 so znašali 175.075,29 EUR.

• Zaključil je tri projekte 7. okvirnega programa sofinancirane v vrednosti 788.888,38 EUR.

Research projects acquired and completed

In 2014, the Institute launched or participated in 20 projects of the Slovenian Research Agency:

• four applied projects (one as the developer) with estimated annual revenues in the amount of

€126,720.62;

• 14 basic projects (six as the developer) with estimated annual revenues in the amount of

€585,317.72;

• two new postdoctoral projects with annual revenues in the amount of €106,522.

• In 2014, the Institute completed basic, applied and postdoctoral projects, generating revenues for the year equalling €436,249.31 (€872,498.62 annual revenues).

In 2014, the Institute:

• ran, as project coordinator, the European strategic project DeFishGear in the total amount of €5.3m (the value of the project for the Institute is €675,112, of which €641,357 is co-financed). Revenues in 2014 equalled €132,140.59;

• participated in six projects within the 7th

Framework Programme of the EU. Revenues in 2014 equalled €445,516.18;

• coordinated the implementation of the EUROLIS project as part of the 7th Framework Programme of the European Community in the total amount of €3.9m (the value of the project for the Institute is €782,630, of which €633,830 is co-financed).

Revenues in 2014 equalled €175,075.29;

• completed three projects as part of the 7th Framework Programme valued at €788,888.38;

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• Pridobil je projekt ERA-NET ERASynBio in ga začel izvajati. Projekt se je začel izvajati 15. 9. 2014 in traja tri leta. Vrednost projekta je 450.000 EUR, od tega 400.000 EUR za KI. Prihodki v letu 2014 so znašali 20.445,91 EUR

• Zaključil je projekt ERA NET Storeheat. Prihodki v letu 2014 so znašali 9.232,33 EUR.

• Zaključil je projekt PLASTICE programa Central Europe. Prihodki v letu 2014 so znašali 91.721,47 EUR.

• Zaključil je projekt Trans2Care. Prihodki v letu 2014 so znašali 19.114,27 EUR.

• Izvajal je projekt Life project Prosil v vrednosti 104.298 EUR. Prihodki v letu 2014 so znašali 18.989,91 EUR.

• Zaključil je projekt Nova generacija raziskovalcev ved o življenju (vrednost celotnega projekta je 700.000 EUR, vrednost projekta za KI je 366.383 EUR).

Prihodki v letu 2014 so znašali 146.429,11 EUR.

• Začel je izvajati prvi projekt iz programa Horizon2020 MefCO2. Projekt se je začel izvajati decembra 2014, traja štiri leta, njegova pogodbena (in sofinancirana) vrednost za KI pa je 1.195.300 EUR.

• Začel je izvajati projekt iz sheme NEwFELPRO.

Projekt se dve leti izvaja na KI. Vrednost projekta za KI je 96.400 EUR.

• 11 podoktorskih raziskovalcev na začetku kariere je v letu 2014 izvajalo projekte, pridobljene leta 2013 na razpisu za spodbujanje raziskovalcev na začetku kariere. Projekte financira Ministrstvo za izobraževanje, znanost in šport (MIZŠ) posredno iz sredstev Evropske skupnosti. V letu 2014 so prihodki znašali 536.448 EUR.

• acquired and began implementing ERA-NET ERASynBio. The project was launched on 15 September 2014 and will last for three years. It is valued at €450,000, of which the National Institute of Chemistry will receive €400,000. Revenues in 2014 equalled €20,445.91;

• completed the ERA NET Storeheat project. Revenues in 2014 equalled €9,232.33;

• the PLASTICE project within the Central Europe Programme has ended (revenues in 2014 equalled

€91,721.47);

• completed the Trans2Care project (revenues in 2014 equalled €19,114.27);

• implemented the Life Prosil project valued at

€104,298 (revenues in 2014 equalled €18,989.91);

• completed the Life sciences researchers: the next generation project (the value of the entire project is €700,000, of which €366,383 is the Institute’s share). Revenues in 2014 equalled €146,429.11;

• began implementing the first project within the Horizon2020 MefCO2 programme. work on the project began in December 2014 and will last four years; its contractual (and co-financed) value for the National Institute of Chemistry is €1,195,300;

• began implementing a project within the NEwFELPRO scheme. The project will run at the National Institute of Chemistry for two years. The value of the project for the Institute is €96,400;

• 11 postdoctoral researchers at the beginning of their career carried out projects in 2014 that were obtained in 2013 at a tender for the promotion of early career researchers. The projects are indirectly funded by the Ministry of Education, Science and Sport from the resources of the European Union.

Revenues in 2014 equalled €536,448.

Investments

In 2014, the Institute invested €1,489,855 in fixed assets. The successful acquisition of external financial resources contributed to making these investments possible. In this year, we launched two reconstruction projects: for the extension and for the old building of the Institute. They are scheduled for completion in 2015. The estimated values of reconstructing the extension and the old building of the Institute are

€2,237,029 and €1,714,520, respectively. Both reconstruction projects will be co-financed by the relevant ministry – 85% of the funds raised will be provided by the European Regional Development Fund and 15% by the Republic of Slovenia.

In 2014, the Institute invested €1,244,704 in equipment, €178,288 in real estate and made €66,863 worth of other investments.

Some of our new acquisitions of higher value research equipment are:

• Agilent Mass Spectrometer with Ionisation

• Laser Ablation Analyte G2 EXCIMER

• Device for the measurement of molecular interactions

• Agilent 1260 Infinity HPLC System

• MPG2 Potentiostat

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ZAPOSLENI IN IZOBRAŽEVANjE

Število zaposlenih na Kemijskem inštitutu se je v letu 2014 z 285 povečalo na 287 zaradi nadomeščanja porodniških dopustov v splošnem sektorju. Glede na leto 2013 je skupno število raziskovalcev, mladih raziskovalcev in strokovnega osebja (torej zaposlenih v znanstvenem sektorju) ostalo nespremenjeno, število administrativnega osebja (zaposlenih v sektorju skupnih služb) pa se je povečalo za sedem odstotkov.

Leta 2014 je na Kemijskem inštitutu začelo delati 11 novih mladih raziskovalcev, usposabljanje pa je končalo 13 mladih raziskovalcev.

Konec leta 2014 je bilo na Kemijskem inštitutu 287 zaposlenih, od tega 131 doktorjev znanosti, štirje magistri, 120 visoko izobraženih, osem višje izobraženih in 24 srednje ali nižje izobraženih.

V tujih raziskovalnih organizacijah se je dlje od enega meseca usposabljalo 23 zaposlenih na inštitutu.

Z inštitutom je v letu 2014 sodelovalo 52 tujih

raziskovalcev, štirje tuji raziskovalci pa so se v letu 2014 na inštitutu zaposlili.

Število zaposlenih na dan 31. 12. 2014

Number of employees (31 December 2014) 287

Število sklenjenih pogodb o zaposlitvi

Number of employment contracts 48

Število prenehanj delovnega razmerja

Number of terminations of employment 45

Število mladih raziskovalcev (skupaj z MR iz gospodarstva) Early-stage researchers (including ESR from the economic sector)

56 + 3

iz gospodarstva from the economic sector Število zaključenih šolanj mladih raziskovalcev

Number of early-stage researchers who completed training 13

Število usposabljanj v tujini (več kot mesec dni)

Number of trainings abroad (lasting over a month) 23

Število sodelujočih tujih raziskovalcev

Number of participating foreign researchers 52

Število zaposlitev tujih raziskovalcev v letu 2014

Number of foreign researchers employed in 2014 4

Tabelarični prikaz podatkov o zaposlenih / Tabular presentation of employee data

EMPLOYEES AND EDUCATION

The number of employees at the National Institute of Chemistry increased from 285 to 287 in 2014 due to substitutes for maternity leave in the general sector.

Compared to 2013, the total number of researchers, early-stage researchers and professional staff (i.e.

employees in the science sector) remained unchanged, while the number of administrative staff (employees in the sector of common services) increased by 7%.

11 new early-stage researchers started working and 13 early-stage researchers completed their training at the National Institute of Chemistry in 2014.

At the end of 2014, the National Institute of Chemistry employed 287 people, of which 131 with a PhD, four with an MSc, 120 with higher education, eight with higher vocational education and 24 with secondary education or lower.

23 Institute employees underwent training at foreign research organisations lasting for more than one month.

52 foreign researchers collaborated with the Institute and four foreign researchers obtained employment at the Institute in 2014.

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MAGISTERIj / MSC

4

287 SKUPAj / TOTAL

ŠT. DOKTORjEV

131

NO. OF PHDS VISOKA IZOBR.

120

HIGHER EDUCATION

OSTALI / REST

24

VIŠjA

8

HIGHER VOCATIONAL

Izobrazbena struktura zaposlenih na dan 31.12.2014 / Educational structure of employees on

31. December 2014

Social responsibility

The National Institute of Chemistry continues to affirm its commitment to social responsibility as an associate member in the United Nations Global Compact initiative.

with associate membership, we have voluntarily undertaken to respect and promote the fundamental principles of social responsibility.

with the aim of improving the conditions, regularity and efficiency of work, we have once again obtained the following certificates:

• ISO 9001,

• European Green Office (EGO) certificate, which confirms that the National Institute of Chemistry meets the requirements of the basic level of good environmental practice in offices according to the EGO criteria.

Družbena odgovornost

Kemijski inštitut tudi to leto, kot že nekaj let, zavezo družbeni odgovornosti potrjuje kot pridruženi član v pobudi Združenih narodov Global Compact.

S pridruženim članstvom smo se prostovoljno obvezali, da bomo spoštovali in promovirali temeljna načela družbene odgovornosti.

Da bi izboljšali pogoje ter urejenost in učinkovitost dela smo tudi letos pridobili certifikata:

• ISO 9001,

• Certifikat European Green office (EGO) – Evropska zelena pisarna, ki potrjuje, da Kemijski inštitut dosega zahteve osnovne stopnje dobre okoljske prakse v pisarniški dejavnosti po merilih EGO.

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Doktorati, magisteriji in diplome v letu 2014

Doctoral, Master’s and Graduate Theses in year 2014

Grafični prikaz: Doktorati, magisteriji in diplome v letih 2002 - 2014.

Graphical representation: Ph.D., M.Sc. and B.Sc. Theses in years 2002 - 2014.

DOKTORATI / DOCTORAL THESES

Metka Novak L11 12.2.2014

Ema Šušteršič L03 30.5.2014

Ubrani Mruthunjayappa Manu Patel L10 23.6.2014

Sebastiano Dal Borgo L04 30.6.2014

Matej Repič L01 2.7.2014

Martina Lenarčič Živković L15 18.7.2014

Ana Obradović L13 2.10.2014

Peter Perdih L07 2.10.2014

Žiga Velišček L10 24.11.2014

Slavko Rast L15 2.12.2014

Andrea Kišić L15 2.12.2014

Aleksander Rauter L10 8.12.2014

Tomaž Čendak L09 22.12.2014

100

80

60

40

20

0

2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014

51 40 49 51 33 46 50 62 60 92 72 91 70

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Število diplom, magisterijev, doktoratov, mentorstev in komentorstev s strani zaposlenih na KI

Number of B.Sc., M.Sc., Ph.D. Theses, mentorships and comentorships by employees of NIC

Objave in citiranost v letu 2014

V letu 2014 je Kemijski inštitut beležil 285 objav, ki zajemajo članke, knjige, poglavja in patente. Povprečni faktor vpliva revij, v katerih so v letu 2014 objavljali raziskovalci Kemijskega inštituta, je znašal 3,748, kar predstavlja znatno izboljšanje glede na preteklo leto. Povprečno mesto v letu 2014, ki ga zaseda revija na določenem področju, je bilo 26, kar ravno tako izkazuje izboljšanje glede na preteklo leto. Citiranost znanstvenih del naših raziskovalcev, ki je pomemben kazalnik uspešnosti, je v letu 2014 znašala 6139 čistih citatov. Vse to omogoča tako večjo konkurenčnost pri prijavi mednarodnih in domačih raziskovalnih projektov kot tudi večjo prepoznavnost v raziskovalnih krogih na posameznih področjih raziskovanja.

Posebej velja izpostaviti dosežke skupine slovenskih znanstvenikov iz Laboratorija za biotehnologijo (L12), ki so rezultate svojega dela objavili v prestižnih revijah Nature Chemical Biology (s faktorjem vpliva 13,2) in Nature Communications (faktor vpliva 10,7), ter znanstvenike Nacionalnega centra za NMR- spektroskopijo visoke ločljivosti (L-15), ki sta jim uspeli objavi v reviji Angewandte Chemie, kjer je faktor vpliva znašal 11,3, ter v reviji Nature Communications

Publications and citations in 2014

In 2014, the National Institute of Chemistry had 285 publications, which includes articles, books, chapters and patents. The average impact factor of the journals in which researchers of the National Institute of Chemistry published in 2014 was 3.748, which is a significant improvement over the year before. In 2014, the average ranking of a journal in a given field was 26, which is also an improvement compared to the previous year.

The number of citations of our researchers’ works, an important indicator of success, equalled 6139 citations (excluding self-citations) in 2014. All of this allows greater competitiveness in the application of international and domestic research projects, as well as greater visibility in research circles in specific research areas.

Especially notable achievements were made by the group of Slovenian scientists from the Laboratory of Biotechnology (L12) who published the results of their work in the prestigious journals Nature Chemical Biology (impact factor 13.2) and Nature Communications (impact factor 10.7), as well as by scientists from the Slovenian NMR Centre (L15) who were published in Angewandte Chemie, with an impact factor of 11.3, and 35 diplom / Undergraduate Theses

11 magisterijev / Master's Theses 23 doktoratov / Doctoral Theses

29 mentorstev pri diplomah / Mentorships of Undergraduate Theses 6 mentorstev pri magisterijih / Mentorships of Master's Theses 13 mentorstev pri doktoratih / Mentorships of Doctoral Theses

5 komentorstev pri diplomah / Comentorships of Undergraduate Theses 7 komentorstva pri magisterijih / Comentorships of Master's Theses 4 komentorstev pri doktoratih / Comentorships of Doctoral Theses

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s faktorjem vpliva 10,7. Ti izjemni dosežki predstavljajo znaten doprinos k utrjevanju ugleda slovenskih znanstvenikov v svetu.

in Nature Communications, whose impact factor is 10.7.

These exceptional achievements represent a significant contribution to solidifying the reputation of Slovenian scientists around the world.

Leto / Year Št. objavljenih del

Nr. of published works Povprečni IF

Average IF Povprečno mesto revije

Average journal position Citiranost Citations

2010 229 3,297 31 4621

2011 295 3,339 33 5301

2012 311 3,647 23 5990

2013 281 3,095 28 6601

2014 285 3,748 26 6139

Objavljena dela v letu (članki, knjige, poglavja, patenti) / Published works by year (articles, books, chapters, patents), average IF, average journal position and number of citations.

Članki, objavljeni v revijah z največjim faktorjem vpliva:

Articles published in journals with the highest impact factor:

Originalna znanstvena dela / Original scientific works

1. IF=13,2 L12

GABER, Rok, LEBAR, Tina, MAjERLE, Andreja, ŠTER, Branko, DOBNIKAR, Andrej, BENČINA, Mojca, jERALA, Roman. Designable DNA-binding domains enable construction of logic circuits in mammalian cells.

Nature Chemical Biology, ISSN 1552-4450, Mar. 2014, vol. 10, no.

3, str. 203-208, ilustr. http://www.

nature.com/nchembio/journal/

vaop/ncurrent/full/nchembio.1433.

html, doi: 10.1038/nchembio.1433.

[COBISS.SI-ID 5408026]

2. IF=11,3 NMR

ČERU, Slavko, ŠKET, Primož, PRISLAN, Iztok, LAH, jurij, PLAVEC, janez. A new pathway of DNA G-quadruplex formation.

Angewandte Chemie, ISSN 1433- 7851. [Print ed.], 2014, vol. 53, issue 19, str. 4881-4884, ilustr.

http://onlinelibrary.wiley.com/

doi/10.1002/anie.201400531/

pdf, doi: 10.1002/anie.201400531.

3.-4. IF=10,7 L12

LEBAR, Tina, BEZELjAK, Urban, GOLOB, Anja, jERALA, Miha, KADUNC, Lucija, PIRŠ, Boštjan, STRAŽAR, Martin, VUČKO, Dušan, ZUPANČIČ, Uroš, BENČINA, Mojca, FORSTNERIČ, Vida, GABER, Rok, LONZARIĆ, jan, MAjERLE, Andreja, OBLAK, Alja, SMOLE, Anže, jERALA, Roman. A bistable genetic switch based on designable DNA-binding domains. Nature Communications, ISSN 2041-1723, Sep. 2014, vol. 5, str. 1-13, 5007, ilustr. http://www.

nature.com/ncomms/2014/140929/

ncomms6007/full/ncomms6007.

html, doi: 10.1038/ncomms6007.

3.-4. IF=10,7 NMR

KOCMAN, Vojč, PLAVEC, janez. A tetrahelical DNA fold adopted by tandem repeats of alternating GGG and GCG tracts. Nature Communications, ISSN 2041- 1723, Dec. 2014, vol. 5, str. 1-11, 5831, ilustr. http://www.nature.

com/ncomms/2014/141215/

ncomms6831/pdf/ncomms6831.pdf, doi: 10.1038/ncomms6831. [COBISS.

SI-ID 5625626]

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5. IF=9,8 L01, L12

AVBELj, Monika, wOLZ, Olaf- Oliver, FEKONjA, Ota, BENČINA, Mojca, REPIČ, Matej, MAVRI, janez, KRÜGER, jens, SCHÄRFE, Charlotta, DELMIRO-GARCIA, Magno, PANTER, Gabriela, KOHLBACHER, Oliver, wEBER, Alexander N. R., jERALA, Roman. Activation of lymphoma- associated MyD88 mutations via allostery-induced TIR domain oligomerization. Blood, ISSN 0006- 4971, Dec. 2014, vol. 124, iss. 26, str.

3896-3904. http://www.bloodjournal.

org/content/early/2014/10/30/

blood-2014-05-573188.full- text.pdf+html, doi: 10.1182/

blood-2014-05-573188. [COBISS.SI-ID 5607194]

6.-7. IF=8,8 L11

GODINIĆ MIKULČIĆ, Vlatka, jARIĆ, jelena, GREBER, Basil j., FRANKE, Vedran, HODNIK, Vesna, ANDERLUH, Gregor, BAN, Nenad, wEYGAND- DURAŠEVIĆ, Ivana. Archaeal aminoacyl-tRNA synthetases interact with the ribosome to recycle tRNAs. Nucleic Acids Research, ISSN 0305-1048, Apr.

2014, vol. 42, no. 8, str. 5191-5201.

http://nar.oxfordjournals.org/

content/early/2014/02/24/nar.

gku164.abstract?sid=ade8c1b0- cd71-47bb-bcd5-fe03a8a4c211%z, doi: 10.1093/nar/gku164. [COBISS.

SI-ID 37292293]

6.-7. IF=8,8 L17

KONC, janez, jANEŽIČ, Dušanka.

ProBiS-ligands: a web server for prediction of ligands by examination of protein binding sites. Nucleic Acids Research, ISSN 0305-1048, jul.

2014, vol. 42, no. w1, str. w215-w220.

http://nar.oxfordjournals.org/

content/42/w1/w215.full.pdf+html, doi: 10.1093/nar/gku460. [COBISS.

SI-ID 5514010]

8. IF=8,6 NMR

BUSSCHAERT, Nathalie,

KARAGIANNIDIS, Louise E., wENZEL, Marco, HAYNES, Cally j.E., wELLS, Neil j., YOUNG, Philip G., MAKUC, Damjan, PLAVEC, janez, jOLLIFFE, Katrina A., GALE, Philip A. Synthetic transporters for sulfate: a new method for the direct detection of lipid bilayer sulfate transport. Chemical Science, ISSN 2041-6520, Mar. 2014, vol. 5, iss.

3, str. 1118-1127, ilustr. http://pubs.

rsc.org/en/content/articlepdf/2014/

sc/c3sc52006d, doi: 10.1039/

C3SC52006D. [COBISS.SI-ID 5420570]

9. IF=7,9 L11

KOSTAN, julius, SALZER, Ulrich, ORLOVA, Albina, TÖRŐ, Imre, HODNIK, Vesna, SENjU, Yosuke, ZOU, juan, SCHREINER, Claudia, STEINER, julia, MERILÄINEN, jari, NIKKI, Marko, VIRTANEN, Ismo, CARUGO, Olivero, RAPPSILBER, juri, LAPPALAINEN, Pekka, LEHTO, Veli-Pekka, ANDERLUH, Gregor, EGELMAN, Edward H., DjINOVIĆ CARUGO, Kristina. Direct interaction of actin filaments with F-BAR protein pacsin2. EMBO Reports, ISSN 1469-221X, Nov. 2014, vol. 15, no. 11, str. 1154-1162. http://embor.

embopress.org/content/15/11/1154, doi: 10.15252/embr.201439267.

10. IF=7,1 L10

UBRANI M., Manu Patel, DOMINKO, Robert. Application of in operando UV/Vis spectroscopy in lithium-sulfur batteries. ChemSusChem, ISSN 1864-564X. Online izd., Aug. 2014, vol. 7, iss. 8, str. 2167-2175. http://

onlinelibrary.wiley.com/doi/10.1002/

cssc.201402215/pdf, doi: 10.1002/

cssc.201402215. [COBISS.SI-ID 5536794]

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Pregledna znanstvena članka / Review Articles

1. IF=13,5 L11

GILBERT, Robert j., DALLA SERRA, Mauro, FROELICH, Christopher j., wALLACE, Mark I., ANDERLUH, Gregor.

Membrane pore formation at protein- lipid interfaces. TiBS, ISSN 0968- 0004. [Regular ed.], Nov. 2014, vol.

39, issue 11, str. 510-516, ilustr. http://

www.cell.com/trends/biochemical- sciences/pdf/S0968-0004(14)00165- 0.pdf, doi: 10.1016/j.tibs.2014.09.002.

2. IF=8,7 L17

KONC, janez, jANEŽIČ, Dušanka.

Binding site comparison for function prediction and pharmaceutical discovery. Current Opinion in Structural Biology, ISSN 0959-440X. [Print ed.], Apr. 2014, vol. 25, str. 34-39. http://www.

sciencedirect.com/science/article/

pii/S0959440X1300208X, doi:

10.1016/j.sbi.2013.11.012. [COBISS.

SI-ID 5395738]

Bibliografija inštituta v letu 2014

ANALITIČNI PODATKI (tipologija COBISS /laboratoriji)

Dela / Works L01 L03 L04 L05 L06 L07 L09 L10 L11 L12 L13 L14 L15 L16 L17 BRUTO Dvojniki/

trojniki OVERLAPS

SKUPAJ/ ALL Članki, monografije, poglavja

Articles, monographies, chapters 15 17 11 13 4 32 17 66 34 31 20 10 19 0 15 304 22/4 274

Prispevki na konferencah

Conference contributions 8 25 30 26 17 21 24 89 38 38 21 11 27 0 19 394 28/6 354

Patenti / Patents 0 0 0 1 1 2 0 6 2 2 1 1 1 0 0 17 2/0 15

Predavanja / Lectures 6 1 3 4 2 7 0 7 8 13 1 0 11 1 6 70 0/0 70

Dokumenti / Documents 0 0 5 9 9 1 1 10 0 0 5 0 0 15 0 55 0/0 55

Doktorati, magisteriji, diplome

PhD, MSc, BSc 3 2 1 6 0 5 2 10 12 12 9 0 7 0 0 69 0/0 69

SKUPAJ / ALL UNITS 32 45 50 59 33 68 44 188 94 96 57 22 65 16 40 909 52/10 837

837 BIBLIOGRAFIjA INŠTITUTA

SKUPAj V LETU 2014

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Institute bibliography for 2014

ANALYTICAL DATA (typology COBISS /laboratories)

Dela / Works L01 L03 L04 L05 L06 L07 L09 L10 L11 L12 L13 L14 L15 L16 L17 BRUTO Dvojniki/

trojniki OVERLAPS

SKUPAJ/

ALL Članki, monografije, poglavja

Articles, monographies, chapters 15 17 11 13 4 32 17 66 34 31 20 10 19 0 15 304 22/4 274

Prispevki na konferencah

Conference contributions 8 25 30 26 17 21 24 89 38 38 21 11 27 0 19 394 28/6 354

Patenti / Patents 0 0 0 1 1 2 0 6 2 2 1 1 1 0 0 17 2/0 15

Predavanja / Lectures 6 1 3 4 2 7 0 7 8 13 1 0 11 1 6 70 0/0 70

Dokumenti / Documents 0 0 5 9 9 1 1 10 0 0 5 0 0 15 0 55 0/0 55

Doktorati, magisteriji, diplome

PhD, MSc, BSc 3 2 1 6 0 5 2 10 12 12 9 0 7 0 0 69 0/0 69

SKUPAJ / ALL UNITS 32 45 50 59 33 68 44 188 94 96 57 22 65 16 40 909 52/10 837

837 INSTITUTE BIBLIOGRAPHY IN YEAR 2014 (ALL)

Bombažna vlakna / Cotton fibres (Milena Zorko)

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2

_ZDA

USA 7. Okvirni program EU / EU 7th Framework Program 6 EU Obzorje2020 projekti / EU Horizon2020 1 NEwFELPRO 1 Transnacionalni program EU

EU transnational cooperation programme 1 Central Europe projekti / Central Europe project 1 jadranski čezmejni strateški projekt IPA

IPA Adriatic Cross-border Cooperation Project 1

Life+ projekt/ Life+ project 1

ERA-NET 2

Skupno / Total 14

MULTILATERALNO SODELOVANjE MULTILATERAL COOPERATION

BILATERALNO SODELOVANjE BILATERAL COOPERATION

18

skupaj / total

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Francija

3

France

Japonska

2

Japan rusija

1

russia

Kitajska

2

China turčija

2

turkey

Hrvaška

6

Croatia

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Uspehi, nagrade in priznanja v letu 2014

Državno odlikovanje Republike Slovenije

(Ljubljana, 3. 3. 2014)

Prof. dr. Roman Jerala, vodja Laboratorija za

biotehnologijo, je prejel državno odlikovanje Republike Slovenije, medaljo za zasluge pri uveljavljanju slovenske znanosti in visokega šolstva v mednarodnem prostoru.

Achievements, awards and recognitions in 2014

Decoration of the Republic of Slovenia

(Ljubljana, 3 March 2014)

Prof. Dr. Roman Jerala, Head of the Laboratory of Biotechnology, received a decoration of the Republic of Slovenia – a medal for accomplishments in the promotion of Slovenian science and higher education in the international arena.

Zoisova nagrada in Puhovo priznanje

(Ljubljana, 24. 11. 2014)

Zoisovo nagrado za življenjsko delo je prejel akademik prof. dr. Janez Levec, vodja Laboratorija za katalizo in kemijsko reakcijsko inženirstvo.

V slovenskem prostoru je eden izmed začetnikov raziskovanja na področju kemijskega inženirstva.

Zelo odmevne so predlagane korelacije za napoved hidrodinamskih parametrov v kapalnem reaktorju in uvedba oksidacije organskih spojin v vodnih raztopinah v prisotnosti trdnega katalizatorja. Proces za oksidacijo organskih polutantov v industrijskih odpadnih vodah je zaščiten s štirimi mednarodnimi patenti.

Prof. dr. Roman jerala in predsednik Republike Slovenije Borut Pahor (foto: STA)

Prof. Dr. Roman jerala and the President of the Republic of Slovenia Borut Pahor (photo by: STA)

The Zois Award and the Puh Award

(Ljubljana, 24 November 2014)

The Zois Award for lifetime achievement was granted to Acad. Prof. Dr. Janez Levec, Head of the Laboratory of Catalysis and Chemical Reaction Engineering.

In Slovenia, he is one of the founders of research into chemical engineering. His proposed correlations for forecasting hydrodynamic parameters in a trickle-bed reactor and the implementation of oxidation of organic compounds in aqueous solutions in the presence of a solid catalyst are highly renowned. The process of the oxidation of organic pollutants in industrial waste waters is protected with four international patents.

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je eden vodilnih teoretikov na svojem področju in predan pedagog, ki svoje znanje prenaša ne le v akademsko okolje, ampak predvsem v industrijo.

Puhovo priznanje je prejela mešana skupina raziskovalcev Laboratorija za molekularno biologijo in nanobiotehnologijo Kemijskega inštituta (L11) ter farmacevtskega podjetja Lek, d. d., za razvoj podobnih bioloških zdravil filgrastim in pegfilgrastim ter njun prenos v proizvodnjo. V skupini so sodelovale mag.

Tanja Milunović in upokojeni sodelavki dr. Vladka Gaberc Porekar ter Ana Jesenko.

Priznanje za življenjsko delo na področju kemometrije

(Richmond, ZDA, 12. 6. 2014)

Zaslužni profesor Kemijskega inštituta, dr. Jurij Zupan, je na 14. konferenci CAC 2014 (14^th Conference on Chemometrics in Analytical Chemistry) v Richmondu, ZDA, prejel prestižno priznanje za življenjsko delo na področju kemometrije.

Akademik prof. dr. janez Levec Acad. Prof. Dr. janez Levec

Dr. jurij Zupan (KI) in profesor Yvan Vander Heyden, Vrije Univeriteit Brussels

Dr. jurij Zupan (National Institute of Chemistry) and Professor Yvan Vander Heyden, Vrije Univeriteit Brussels

He is one of the leading theoreticians in his field and he is a dedicated pedagogue who transfers his knowledge not only within the academic environment but also to industry.

The Puh Award was conferred for development of biosimilar drugs filgrastim and pegfilgrastim and their transfer into production, to the mixed research group from pharmaceutical company Lek and National Institute of Chemistry, with participation of the following colleagues from the Laboratory for Molecular Biology and Nanobiotechnology (L11): mag. Tanja Milunović, dr. Vladka Gaberc Porekar and Ana Jesenko (both retired).

Chemometrics Lifetime Achievement Award

(Richmond, US, 12 june 2014)

Professor Emeritus of the National Institute of

Chemistry Dr. Jurij Zupan was awarded the prestigious Chemometrics Lifetime Achievement Award at the 14^th Conference on Chemometrics in Analytical Chemistry in Richmond, US.