Electronic Supporting Information for
Novel Structural hybrids of prrrole and thiazole moieties:
Synthesis and evaluation of antibacterial and antifungal activities
Mohamed A. Salema, Samir Y. Abbasb, Marwa A. M. Sh. El-Shariefa,c, Mohamed H.
Helald, Moustafa A. Goudae
aDepartment of Chemistry, Faculty of Science and Arts, King Khalid University, Mohail, Assir, Saudi Arabia
bOrganometallic and Organometalloid Chemistry Department, National Research Centre, Cairo, Egypt
cApplied Organic Chemistry Department, National Research Centre, Cairo, Egypt
d Department of Chemistry, Faculty of Arts and Science, Northern Border University, Rafha, KSA
eDepartment of Chemistry, Faculty of Science and Arts, Ulla, Taibah University, Medina, Saudi Arabia
*Corresponding author. Tel.: +202 33335929; Fax: +202 33370931. E-mail address:
samiryoussef98@yahoo.com
0.0 0.5 1.0 1.5 2.0 2.5 3.0 3.5 4.0 4.5 5.0 5.5 6.0 6.5 7.0 7.5 8.0 8.5 9.0 9.5 10.0 10.5 11.0 11.5 12.0
f1 (ppm)
-2000 0 2000 4000 6000 8000 10000 12000 14000 16000 18000 20000 22000 24000 26000 28000 30000 32000 34000
3.03
3.00
1.03
1.06
0.99
1.02
1.03
1.00 3.013.02
3.80
6.076.086.086.096.516.51
6.936.946.94
7.877.888.04
11.14
-10 0
10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210
f1 (ppm)
-20 0 20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380
31.37
36.51
108.73
114.85
127.34128.28
136.32
177.49
0.5 1.0 1.5 2.0 2.5 3.0 3.5 4.0 4.5 5.0 5.5 6.0 6.5 7.0 7.5 8.0 8.5 9.0 9.5 10.5
11.5 12.5
f1 (ppm)
0 500 1000 1500 2000 2500 3000 3500 4000 4500
2.86
0.96
0.95
0.970.931.881.86
0.98
0.99
1.00 3.86
6.116.116.126.126.636.64
6.997.187.337.357.377.637.65
8.15
9.55
11.55
0.0 0.5 1.0 1.5 2.0 2.5 3.0 3.5 4.0 4.5 5.0 5.5 6.0 6.5 7.0 7.5 8.0 8.5 9.0 9.5 10.5
11.5 12.5
f1 (ppm)
0 500 1000 1500 2000 2500 3000 3500 4000
4.95
1.02
1.01
1.05
1.00
1.04 3.863.87
6.116.126.126.556.566.56
7.01
8.25
11.84
0.0 0.5
1.0 1.5
2.0 2.5
3.0 3.5
4.0 4.5
5.0 5.5
6.0 6.5
7.0 7.5
8.0 8.5
9.0 9.5
10.0
f1 (ppm)
-1000 0 1000 2000 3000 4000 5000 6000 7000 8000 9000 10000 11000 12000 13000 14000
2.98
2.831.98
1.02
1.06
1.00
1.00 3.16
3.883.92
6.13
6.596.59
7.03
8.35
10 20
30 40
50 60
70 80
90 100
110 120
130 140
150 160
170 180
190 200
f1 (ppm)
0 100 200 300 400 500 600 700 800 900 1000
29.7732.5437.02
109.00
117.49
127.55129.74
150.00
162.69
172.61
0.0 0.5
1.0 1.5
2.0 2.5
3.0 3.5
4.0 4.5
5.0 5.5
6.0 6.5
7.0 7.5
8.0 8.5
9.0 9.5
10.0
f1 (ppm)
-100 0 100 200 300 400 500 600 700 800 900 1000 1100 1200 1300 1400 1500 1600 1700 1800 1900 2000
2.78
1.99
1.01
1.06
1.00
1.780.971.81
1.06 3.88
4.07
6.096.106.116.526.526.536.53
7.027.377.397.457.477.517.537.54
8.15
1.0 1.5 2.0 2.5 3.0 3.5 4.0 4.5 5.0 5.5 6.0 6.5 7.0 7.5 8.0 8.5 9.0 9.5 10.0 10.5 11.0 11.5 12.0 12.5
f1 (ppm)
-200 0 200 400 600 800 1000 1200 1400 1600 1800 2000 2200 2400 2600 2800
2.89
2.64
1.05
1.00
0.99
0.95
0.99
0.86 1.491.50
3.874.144.164.174.19
6.116.126.126.556.556.56
7.01
8.25
11.80
2.0 2.5
3.0 3.5
4.0 4.5
5.0 5.5
6.0 6.5
7.0 7.5
8.0 8.5
9.0 9.5
10.0 10.5
11.0 11.5
12.0
f1 (ppm)
-1000 0 1000 2000 3000 4000 5000 6000 7000 8000 9000 10000 11000 12000 13000 14000 15000 16000 17000
2.99
2.96
1.000.920.98
1.00
1.01
0.97
0.0 0.5
1.0 1.5
2.0 2.5
3.0 3.5
4.0 4.5
5.0 5.5
6.0 6.5
7.0 7.5
8.0 8.5
9.0 9.5
10.0
f1 (ppm)
0 5000 10000 15000 20000 25000 30000 35000 40000
3.04
1.485.81
3.02
0.981.00
1.01
1.00
1.01 2.12
3.313.35
3.86
5.955.956.056.066.076.386.396.396.40
6.89
8.17
-10 0
10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210
f1 (ppm)
0 50 100 150 200 250 300 350 400 450 500 550
14.21 600
31.48
36.86
95.69
108.40
114.34
127.78128.77
136.52
143.22
168.37
0.0 0.5 1.0 1.5 2.0 2.5 3.0 3.5 4.0 4.5 5.0 5.5 6.0 6.5 7.0 7.5 8.0 8.5 9.0 9.5 10.5
11.5 12.5
f1 (ppm)
0 500 1000 1500 2000 2500 3000 3500 4000
2.95
1.00
1.00
1.010.930.811.91
1.951.00
0.80 3.87
6.076.086.096.406.416.416.426.937.257.297.387.40
7.847.867.98
11.77
0.0 0.5
1.0 1.5
2.0 2.5
3.0 3.5
4.0 4.5
5.0 5.5
6.0 6.5
7.0 7.5
8.0 8.5
9.0 9.5
10.0
f1 (ppm)
0 500 1000 1500 2000 2500 3000 3500 4000 4500 5000 5500
2.99
2.95
1.010.930.98
0.98
4.86
1.00 3.27
3.89
6.086.086.096.326.436.44
6.93
7.50
8.23
